Interplay between hashish and medicines: professionals and cons

A drug interaction occurs when two or more compounds come in contact with each other and produce an effect. Because of its broad spectrum of effects, cannabis can cause a variety of drug interactions.

In this article, we’re going to give you a general idea of ​​how cannabis can interact with some of the most common medicines. Please note, however, that this article is in no way intended to constitute medical advice regarding cannabis and medicinal products.

Drug interactions are not to be played with and can be fatal. Always speak to your doctor before adding anything to your current medication regimen.

Cannabis and antidepressants

We still know very little about the interactions between cannabis and antidepressants (pharmaceuticals) as few studies have taken place. A big part of the reason for this is the fact that we are all unique. You can give two people the same strain and antidepressant and get two completely different reactions. Plus, each strain can contain a completely different mix of cannabinoids and terpenes. It’s hard to say how each person will react.

Some studies of the treatment of depression with cannabis have been done and the results have been mostly positive. The benefit that most people found was the ability to use cannabis to treat depression as the moment required. Since antidepressants are usually taken once a day, cannabis can be used as a breakthrough booster.

Cannabis interaction with sedatives

Sedatives work by slowing down the mechanisms in the central nervous system, and cannabis affects the same receptors. Because of this, cannabis use can increase the effects of sedatives. In fact, there are some studies showing that regular cannabis users often need more medication for sedation in the operating room. If you are sedating and thinking about using cannabis, you should start very slowly in a comfortable environment.


Because the endocannabinoid system regulates our pain receptors, cannabis can increase the effects of pain relievers. Cannabis targets our CB1 and CB2 receptors, which in turn send messages to our opiate receptors. Depending on the person and the circumstances, this can be both desirable and very dangerous.

Cannabis and pain relievers

advantages of Iincluding cannabis with pain relievers Pharmaceutical drugs:

  • Pain and anxiety can be relieved by taking lower doses of medicines.
  • With a wide range of therapeutic effects, cannabis can alleviate some of the negative side effects associated with prescription pain relievers. By indirectly targeting an overstimulated receptor, cannabis can be an effective treatment for opiate withdrawal.

Disadvantages of including cannabis in pain relievers Pharmaceutical drugs:

  • In some cases, combining these drugs with cannabis can cause drowsiness, dizziness, nausea, and vomiting.

Important Tip – When it comes to using cannabis with pain relievers, the key to success is being sure of your dose. Start slowly and test the effect by using far less than you normally would. After all, you can always take more.


Not much research is done on the interaction between cannabis and stimulants. From what we know, these substances seem to work in harmony with each other, and one negates the side effects of using the other. Stimulants are used to treat conditions such as ADD, ADHD, and narcolepsy, but they can cause side effects such as anxiety, restlessness, and high blood pressure.

Cannabis can relax the system, but it can lead to fatigue and brain fog. Cannabis helps relieve stimulants while the stimulants reduce fatigue and brain fog. However, there is a risk of danger here. Both substances individually increase your heart rate. Concomitant use can increase this effect and cause serious cardiovascular risk.

Blood pressure medication

Cannabis causes a vasodilation effect, and when the veins open, blood pressure drops. The heart has to work harder to pump blood, which leads to an increased heart rate. Because of these effects, we can say that cannabis lowers blood pressure (but remember, this is still a generalization). Studies have shown that body positioning, cannabinoid levels, and physiology change our blood pressure. Until we have more data from human studies, take it easy on cannabis and blood pressure medications.

Cannabis and Pharmaceutical drugs for high blood pressure::

Cannabis can help lower high blood pressure, but it is widely used to treat some of the negative side effects of these drugs. It should not be used to replace high blood pressure medication without proper medical supervision.

Cannabis and Medicines for low blood pressure::

Given the effects, we can assume that consuming cannabis can lower blood pressure – but the truth is, we don’t know. If you are treating this condition with medication, speak to your doctor before trying cannabis.

Cannabis and Medicines

There are innumerable combinations that cause an interaction, be it positive or negative. Plants are no exception as herbs can be very powerful, especially cannabis. When using a medicine, you should know that it can interact with cannabis and have an idea of ​​what to expect. Talk to your doctor because after all, not every drug interaction is a bad thing.

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