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In the most recent study, the researchers note that there is growing evidence that the endocannabinoid system (ECS) may be involved in the pathophysiology of obsessive-compulsive disorder. Consistent with this hypothesis, it is suggested from a limited number of case studies that CBM (cannabimovon) might be effective in treating obsessive-compulsive disorder. “
Using the serotonin model, which is why doctors prescribe selective serotonin reuptake inhibitors, cannabis can potentially benefit people with obsessive-compulsive disorder or related anxiety disorders by either promoting equilibrium with the ECS or regulating the presence of serotonin. Since the ECS suffers when someone is under high stress, cannabis’ ability to reduce stress can also help the condition.
The study, led by Natalia Szejko of Yale University’s School of Medicine, includes a case report from a 22-year-old, as well as an overview of relevant animal studies, an overview of studies on the effects of cannabis on people with OCD, and a review of the studies on the effects of cannabis on patients with Tourette’s syndrome.
Before trying cannabis, the 22-year-old patient was prescribed tablets, which he stopped after a week of treatment because of nausea, headache and no beneficial effects. After finding the right concentration of THC, the patient reported a significant reduction in obsessions and compulsions by about 70 percent, as well as general relaxation, improved sleep and focus in school, and an overall improvement in their quality of life that leads to better social functioning and fewer problems at work. “The subject was also able to decrease their nicotine consumption.
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The analysis of the other cases included that of a 38-year-old woman with severe OCD. She found that smoking cannabis on the street improved her symptoms. After switching her treatment to dronabinol, she noted a 50 percent decrease in her obsessive-compulsive disorder. Another patient, a 36-year-old man with schizophrenia and obsessive-compulsive disorder, who did not respond adequately to electroconvulsive therapy, saw marked improvement after adding dronabinol to his treatment.
Another case of a man suffering from unwanted, repetitive sexual and violent thoughts due to brain trauma after being prescribed “Fluvoxamine, Clomipramine, Mirtazapine, Risperidone, Olanzapine, Clozapine, Ziprasidone, Haloperidol, Quetiapine, Memantine, Ondansetron , intravenous ketamine, N-acetylcysteine, gabapentin, clonazepam and mood stabilizers, ”but his symptoms improved after two weeks of dronabinol use.
Similarly, those with Tourette’s syndrome, including a 16-year-old patient suffering from tantrums, have found relief from dronabinol.
This analysis opens the conversation about using cannabis as an alternative to selective serotonin reuptake inhibitors and combining cannabis with traditional therapy to improve the effectiveness of both.